Application Domains
Methods
- Wheat regulation
- Fonio
- Classification of viruses
- Reticulate evolution
- Ancestral genomes and quasi species
An orphan disease is a pathology that does not have effective therapies, mainly due to the lack of prior knowledge and/or the scarcity of these diseases.
Indeed, most orphan diseases are rare diseases ; less than 1/2000 person is affected. According to the Regroupement Québécois des Maladies Orphelines (RQMO), this represents nearly 500,000 people in Quebec. There are more than 7,000 in the world, 80% of which are from genetic origin. Because they have long been little studied, rare diseases are difficult to treat, but also to diagnose.
- Ancestral sequences reconstruction
- Insertion and deletion in comparative genomes
- Statistical Alignment
- profile-profile Alignment
- Stochastic model conception
- Predictiction and characterization of microRNAs in the wheat genome under different stress condition
- Understanding the molecular mechanisms involving miRNAs that regulate plant responses to abiotic stresses as well as the floral transition to flowering in hexaploid wheat
- Functional classification of miRNAs based on the biological and physiological functions of their target genes
- Computational prediction of microRNAs based on structural properties of the putative miRNA-miRNA* duplex
- Genome annotation, genotyping and classification of Viruses
- Identification of sets of patterns in the genome that correlate with the level of risk of the viruses
- Mining Hierarchical Generalized Sequential Patterns
- Ontologie enhancement in bioinformatics
- Development of a platform for bioinformatic tasks automation with simplified acces to popular web ressources (Databases and programs)
- Facilitate bioinformatics education
- Worflow datamining in bioinformatics
- Workflow refactoring